August 28, 2025

Cleanroom Fit‑Out: ISO Levels, Cost Factors, and Market Drivers

For ISO 8/7/6 suites, the largest levers are HVAC/filtration intensity, cleanroom envelope & ceiling systems, and commissioning/validation scope.

Market context

• Semiconductor: CHIPS awards continue for fabs and suppliers (NIST/Commerce, Jan 2025; Commerce, Jan 2025).
• Life sciences: Many lab markets digest excess supply while biomanufacturing is comparatively stronger (JLL 2025).

Cost drivers by ISO class

• Air change rates, filtration, envelope systems (panel vs. stud+liner)
• Ceilings (walkable grid premiums), process utilities, and validation/commissioning

Best practices

• Fix URS early; tie acceptance to validation (IQ/OQ/PQ). See ISPE notes here.
• Coordinate MEP loads and tool/equipment lists before IFC.